PoplarV1, Main, Exploration, bibRecord, 001E73

Bisphosphonate inhibitors reveal a large elasticity of plastidic isoprenoid synthesis pathway in isoprene-emitting hybrid aspen.

Identifieur interne : 001E73 ( Main/Exploration ); précédent : 001E72; suivant : 001E74

Bisphosphonate inhibitors reveal a large elasticity of plastidic isoprenoid synthesis pathway in isoprene-emitting hybrid aspen.

Auteurs : Bahtijor Rasulov ; Eero Talts ; Astrid K Nnaste ; Ülo Niinemets [Estonie]

Source :

Plant physiology [ 1532-2548 ] ; 2015.

RBID : pubmed:25926480

Descripteurs français

KwdFr :
- Alendronate (pharmacologie), Analyse des flux métaboliques (MeSH), Butadiènes (MeSH), Cinétique (MeSH), Complexe protéique du photosystème II (métabolisme), Diphosphonates (pharmacologie), Facteurs temps (MeSH), Feuilles de plante (effets des médicaments et des substances chimiques), Feuilles de plante (effets des radiations), Feuilles de plante (physiologie), Fosfomycine (analogues et dérivés), Fosfomycine (pharmacologie), Hybridation génétique (MeSH), Hémiterpènes (biosynthèse), Lumière (MeSH), Pentanes (MeSH), Photosynthèse (effets des médicaments et des substances chimiques), Photosynthèse (effets des radiations), Plastes (effets des médicaments et des substances chimiques), Plastes (effets des radiations), Plastes (métabolisme), Populus (effets des médicaments et des substances chimiques), Populus (effets des radiations), Populus (métabolisme), Spécificité du substrat (effets des médicaments et des substances chimiques), Spécificité du substrat (effets des radiations), Voies de biosynthèse (effets des médicaments et des substances chimiques), Voies de biosynthèse (effets des radiations), Élasticité (MeSH).
MESH :
- analogues et dérivés : Fosfomycine.
- biosynthèse : Hémiterpènes.
- effets des médicaments et des substances chimiques : Feuilles de plante, Photosynthèse, Plastes, Populus, Spécificité du substrat, Voies de biosynthèse.
- effets des radiations : Feuilles de plante, Photosynthèse, Plastes, Populus, Spécificité du substrat, Voies de biosynthèse.
- métabolisme : Complexe protéique du photosystème II, Plastes, Populus.
- pharmacologie : Alendronate, Diphosphonates, Fosfomycine.
- physiologie : Feuilles de plante.
- Analyse des flux métaboliques, Butadiènes, Cinétique, Facteurs temps, Hybridation génétique, Lumière, Pentanes, Élasticité.

English descriptors

KwdEn :
- Alendronate (pharmacology), Biosynthetic Pathways (drug effects), Biosynthetic Pathways (radiation effects), Butadienes (MeSH), Diphosphonates (pharmacology), Elasticity (MeSH), Fosfomycin (analogs & derivatives), Fosfomycin (pharmacology), Hemiterpenes (biosynthesis), Hybridization, Genetic (MeSH), Kinetics (MeSH), Light (MeSH), Metabolic Flux Analysis (MeSH), Pentanes (MeSH), Photosynthesis (drug effects), Photosynthesis (radiation effects), Photosystem II Protein Complex (metabolism), Plant Leaves (drug effects), Plant Leaves (physiology), Plant Leaves (radiation effects), Plastids (drug effects), Plastids (metabolism), Plastids (radiation effects), Populus (drug effects), Populus (metabolism), Populus (radiation effects), Substrate Specificity (drug effects), Substrate Specificity (radiation effects), Time Factors (MeSH).
MESH :
- chemical , analogs & derivatives : Fosfomycin.
- chemical , biosynthesis : Hemiterpenes.
- chemical , metabolism : Photosystem II Protein Complex.
- chemical , pharmacology : Alendronate, Diphosphonates, Fosfomycin.
- drug effects : Biosynthetic Pathways, Photosynthesis, Plant Leaves, Plastids, Populus, Substrate Specificity.
- metabolism : Plastids, Populus.
- physiology : Plant Leaves.
- radiation effects : Biosynthetic Pathways, Photosynthesis, Plant Leaves, Plastids, Populus, Substrate Specificity.
- chemical : Butadienes, Elasticity, Hybridization, Genetic, Kinetics, Light, Metabolic Flux Analysis, Pentanes, Time Factors.

Abstract

Recently, a feedback inhibition of the chloroplastic 1-deoxy-D-xylulose 5-phosphate (DXP)/2-C-methyl-D-erythritol 4-phosphate (MEP) pathway of isoprenoid synthesis by end products dimethylallyl diphosphate (DMADP) and isopentenyl diphosphate (IDP) was postulated, but the extent to which DMADP and IDP can build up is not known. We used bisphosphonate inhibitors, alendronate and zoledronate, that inhibit the consumption of DMADP and IDP by prenyltransferases to gain insight into the extent of end product accumulation and possible feedback inhibition in isoprene-emitting hybrid aspen (Populus tremula × Populus tremuloides). A kinetic method based on dark release of isoprene emission at the expense of substrate pools accumulated in light was used to estimate the in vivo pool sizes of DMADP and upstream metabolites. Feeding with fosmidomycin, an inhibitor of DXP reductoisomerase, alone or in combination with bisphosphonates was used to inhibit carbon input into DXP/MEP pathway or both input and output. We observed a major increase in pathway intermediates, 3- to 4-fold, upstream of DMADP in bisphosphonate-inhibited leaves, but the DMADP pool was enhanced much less, 1.3- to 1.5-fold. In combined fosmidomycin/bisphosphonate treatment, pathway intermediates accumulated, reflecting cytosolic flux of intermediates that can be important under strong metabolic pull in physiological conditions. The data suggested that metabolites accumulated upstream of DMADP consist of phosphorylated intermediates and IDP. Slow conversion of the huge pools of intermediates to DMADP was limited by reductive energy supply. These data indicate that the DXP/MEP pathway is extremely elastic, and the presence of a significant pool of phosphorylated intermediates provides an important valve for fine tuning the pathway flux.

DOI: 10.1104/pp.15.00470
PubMed: 25926480
PubMed Central: PMC4453795

Affiliations:

Estonie

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 001D13
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Le document en format XML

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<term>Biosynthetic Pathways (drug effects)</term>
<term>Biosynthetic Pathways (radiation effects)</term>
<term>Butadienes (MeSH)</term>
<term>Diphosphonates (pharmacology)</term>
<term>Elasticity (MeSH)</term>
<term>Fosfomycin (analogs & derivatives)</term>
<term>Fosfomycin (pharmacology)</term>
<term>Hemiterpenes (biosynthesis)</term>
<term>Hybridization, Genetic (MeSH)</term>
<term>Kinetics (MeSH)</term>
<term>Light (MeSH)</term>
<term>Metabolic Flux Analysis (MeSH)</term>
<term>Pentanes (MeSH)</term>
<term>Photosynthesis (drug effects)</term>
<term>Photosynthesis (radiation effects)</term>
<term>Photosystem II Protein Complex (metabolism)</term>
<term>Plant Leaves (drug effects)</term>
<term>Plant Leaves (physiology)</term>
<term>Plant Leaves (radiation effects)</term>
<term>Plastids (drug effects)</term>
<term>Plastids (metabolism)</term>
<term>Plastids (radiation effects)</term>
<term>Populus (drug effects)</term>
<term>Populus (metabolism)</term>
<term>Populus (radiation effects)</term>
<term>Substrate Specificity (drug effects)</term>
<term>Substrate Specificity (radiation effects)</term>
<term>Time Factors (MeSH)</term>
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<term>Analyse des flux métaboliques (MeSH)</term>
<term>Butadiènes (MeSH)</term>
<term>Cinétique (MeSH)</term>
<term>Complexe protéique du photosystème II (métabolisme)</term>
<term>Diphosphonates (pharmacologie)</term>
<term>Facteurs temps (MeSH)</term>
<term>Feuilles de plante (effets des médicaments et des substances chimiques)</term>
<term>Feuilles de plante (effets des radiations)</term>
<term>Feuilles de plante (physiologie)</term>
<term>Fosfomycine (analogues et dérivés)</term>
<term>Fosfomycine (pharmacologie)</term>
<term>Hybridation génétique (MeSH)</term>
<term>Hémiterpènes (biosynthèse)</term>
<term>Lumière (MeSH)</term>
<term>Pentanes (MeSH)</term>
<term>Photosynthèse (effets des médicaments et des substances chimiques)</term>
<term>Photosynthèse (effets des radiations)</term>
<term>Plastes (effets des médicaments et des substances chimiques)</term>
<term>Plastes (effets des radiations)</term>
<term>Plastes (métabolisme)</term>
<term>Populus (effets des médicaments et des substances chimiques)</term>
<term>Populus (effets des radiations)</term>
<term>Populus (métabolisme)</term>
<term>Spécificité du substrat (effets des médicaments et des substances chimiques)</term>
<term>Spécificité du substrat (effets des radiations)</term>
<term>Voies de biosynthèse (effets des médicaments et des substances chimiques)</term>
<term>Voies de biosynthèse (effets des radiations)</term>
<term>Élasticité (MeSH)</term>
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<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Fosfomycin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Hemiterpenes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Photosystem II Protein Complex</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Alendronate</term>
<term>Diphosphonates</term>
<term>Fosfomycin</term>
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<term>Plant Leaves</term>
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<term>Substrate Specificity</term>
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<term>Photosynthèse</term>
<term>Plastes</term>
<term>Populus</term>
<term>Spécificité du substrat</term>
<term>Voies de biosynthèse</term>
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<keywords scheme="MESH" qualifier="effets des radiations" xml:lang="fr"><term>Feuilles de plante</term>
<term>Photosynthèse</term>
<term>Plastes</term>
<term>Populus</term>
<term>Spécificité du substrat</term>
<term>Voies de biosynthèse</term>
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<term>Populus</term>
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<term>Plastes</term>
<term>Populus</term>
</keywords>
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<term>Diphosphonates</term>
<term>Fosfomycine</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Feuilles de plante</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Plant Leaves</term>
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<term>Cinétique</term>
<term>Facteurs temps</term>
<term>Hybridation génétique</term>
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<front><div type="abstract" xml:lang="en">Recently, a feedback inhibition of the chloroplastic 1-deoxy-D-xylulose 5-phosphate (DXP)/2-C-methyl-D-erythritol 4-phosphate (MEP) pathway of isoprenoid synthesis by end products dimethylallyl diphosphate (DMADP) and isopentenyl diphosphate (IDP) was postulated, but the extent to which DMADP and IDP can build up is not known. We used bisphosphonate inhibitors, alendronate and zoledronate, that inhibit the consumption of DMADP and IDP by prenyltransferases to gain insight into the extent of end product accumulation and possible feedback inhibition in isoprene-emitting hybrid aspen (Populus tremula × Populus tremuloides). A kinetic method based on dark release of isoprene emission at the expense of substrate pools accumulated in light was used to estimate the in vivo pool sizes of DMADP and upstream metabolites. Feeding with fosmidomycin, an inhibitor of DXP reductoisomerase, alone or in combination with bisphosphonates was used to inhibit carbon input into DXP/MEP pathway or both input and output. We observed a major increase in pathway intermediates, 3- to 4-fold, upstream of DMADP in bisphosphonate-inhibited leaves, but the DMADP pool was enhanced much less, 1.3- to 1.5-fold. In combined fosmidomycin/bisphosphonate treatment, pathway intermediates accumulated, reflecting cytosolic flux of intermediates that can be important under strong metabolic pull in physiological conditions. The data suggested that metabolites accumulated upstream of DMADP consist of phosphorylated intermediates and IDP. Slow conversion of the huge pools of intermediates to DMADP was limited by reductive energy supply. These data indicate that the DXP/MEP pathway is extremely elastic, and the presence of a significant pool of phosphorylated intermediates provides an important valve for fine tuning the pathway flux.</div>
</front>
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<Title>Plant physiology</Title>
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<ArticleTitle>Bisphosphonate inhibitors reveal a large elasticity of plastidic isoprenoid synthesis pathway in isoprene-emitting hybrid aspen.</ArticleTitle>
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<Abstract><AbstractText>Recently, a feedback inhibition of the chloroplastic 1-deoxy-D-xylulose 5-phosphate (DXP)/2-C-methyl-D-erythritol 4-phosphate (MEP) pathway of isoprenoid synthesis by end products dimethylallyl diphosphate (DMADP) and isopentenyl diphosphate (IDP) was postulated, but the extent to which DMADP and IDP can build up is not known. We used bisphosphonate inhibitors, alendronate and zoledronate, that inhibit the consumption of DMADP and IDP by prenyltransferases to gain insight into the extent of end product accumulation and possible feedback inhibition in isoprene-emitting hybrid aspen (Populus tremula × Populus tremuloides). A kinetic method based on dark release of isoprene emission at the expense of substrate pools accumulated in light was used to estimate the in vivo pool sizes of DMADP and upstream metabolites. Feeding with fosmidomycin, an inhibitor of DXP reductoisomerase, alone or in combination with bisphosphonates was used to inhibit carbon input into DXP/MEP pathway or both input and output. We observed a major increase in pathway intermediates, 3- to 4-fold, upstream of DMADP in bisphosphonate-inhibited leaves, but the DMADP pool was enhanced much less, 1.3- to 1.5-fold. In combined fosmidomycin/bisphosphonate treatment, pathway intermediates accumulated, reflecting cytosolic flux of intermediates that can be important under strong metabolic pull in physiological conditions. The data suggested that metabolites accumulated upstream of DMADP consist of phosphorylated intermediates and IDP. Slow conversion of the huge pools of intermediates to DMADP was limited by reductive energy supply. These data indicate that the DXP/MEP pathway is extremely elastic, and the presence of a significant pool of phosphorylated intermediates provides an important valve for fine tuning the pathway flux.</AbstractText>
<CopyrightInformation>© 2015 American Society of Plant Biologists. All Rights Reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rasulov</LastName>
<ForeName>Bahtijor</ForeName>
<Initials>B</Initials>
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<AffiliationInfo><Affiliation>Institute of Agricultural and Environmental Sciences, Estonian University of Life Sciences, 51014 Tartu, Estonia (B.R., E.T., A.K., Ü.N.);Institute of Technology, University of Tartu, 50411 Tartu, Estonia (B.R.); andEstonian Academy of Sciences, 10130 Tallinn, Estonia (Ü.N.).</Affiliation>
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<Author ValidYN="Y"><LastName>Talts</LastName>
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<AffiliationInfo><Affiliation>Institute of Agricultural and Environmental Sciences, Estonian University of Life Sciences, 51014 Tartu, Estonia (B.R., E.T., A.K., Ü.N.);Institute of Technology, University of Tartu, 50411 Tartu, Estonia (B.R.); andEstonian Academy of Sciences, 10130 Tallinn, Estonia (Ü.N.).</Affiliation>
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<Author ValidYN="Y"><LastName>Kännaste</LastName>
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<AffiliationInfo><Affiliation>Institute of Agricultural and Environmental Sciences, Estonian University of Life Sciences, 51014 Tartu, Estonia (B.R., E.T., A.K., Ü.N.);Institute of Technology, University of Tartu, 50411 Tartu, Estonia (B.R.); andEstonian Academy of Sciences, 10130 Tallinn, Estonia (Ü.N.).</Affiliation>
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<Author ValidYN="Y"><LastName>Niinemets</LastName>
<ForeName>Ülo</ForeName>
<Initials>Ü</Initials>
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<AffiliationInfo><Affiliation>Institute of Agricultural and Environmental Sciences, Estonian University of Life Sciences, 51014 Tartu, Estonia (B.R., E.T., A.K., Ü.N.);Institute of Technology, University of Tartu, 50411 Tartu, Estonia (B.R.); andEstonian Academy of Sciences, 10130 Tallinn, Estonia (Ü.N.) ylo.niinemets@emu.ee.</Affiliation>
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Bisphosphonate inhibitors reveal a large elasticity of plastidic isoprenoid synthesis pathway in isoprene-emitting hybrid aspen.

Bisphosphonate inhibitors reveal a large elasticity of plastidic isoprenoid synthesis pathway in isoprene-emitting hybrid aspen.

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